Drug release assays from new chitosan/pHEMA membranes obtained by gamma irradiation

被引：27

作者：

Casimiro, M. H. ^{[1
]}

Gil, M. H. ^{[2
]}

Leal, J. P. ^{[3
,4
,5
]}

机构：

[1] Nucl & Technol Inst, Dept Phys, P-2686953 Sacavem, Portugal

[2] Univ Coimbra, Fac Sci & Technol, Dept Chem Engn, P-3030290 Coimbra, Portugal

[3] Nucl & Technol Inst, Dept Chem, P-2686953 Sacavem, Portugal

[4] Univ Lisbon, Fac Sci, Chem & Biochem Ctr, P-1749016 Lisbon, Portugal

[5] Univ Lisbon, Fac Sci, Dept Chem & Biochem, P-1749016 Lisbon, Portugal

来源：

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS | 2007年 / 265卷 / 01期

关键词：

drug release; gamma radiation; chitosan; membranes; HEMA; amoxicillin;

D O I：

10.1016/j.nimb.2007.09.013

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

With the purpose of obtaining a biocompatible and microbiologically safe matrix that simultaneously could be used as wound dressing material and as a controlled drug release system, membranes with different thickness and different contents in chitosan and hydroxyethyl methacrylate (HEMA) have been prepared by gamma irradiation from a Co-60 source. Antibiotic release experiments were performed before or after irradiation over amoxicillin loaded chitosan/pHEMA membranes in physiological saline solution, and monitored by UV - Vis spectrometry. Results point out a fast amoxicillin release with similar release profile in all studied membranes. The amount of released drug was shown to be dependent on membranes network crosslinking due composition, radiation and membrane thickness. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：406 / 409

页数：4

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