Neural immune pathways and their connection to inflammatory diseases

被引:150
作者
Eskandari, F [1 ]
Webster, JI [1 ]
Sternberg, EM [1 ]
机构
[1] NIMH, Integrat Neurol Immune Program, Sect Neuroendocrine Immunol & Behav, NIH,DHHS, Bethesda, MD 20892 USA
关键词
cytokine; hypothalamic-pituitary-adrenal axis; immune; inflammatory; neural; rheumatoid arthritis;
D O I
10.1186/ar1002
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Inflammation and inflammatory responses are modulated by a bidirectional communication between the neuroendocrine and immune system. Many lines of research have established the numerous routes by which the immune system and the central nervous system (CNS) communicate. The CNS signals the immune system through hormonal pathways, including the hypothalamic - pituitary - adrenal axis and the hormones of the neuroendocrine stress response, and through neuronal pathways, including the autonomic nervous system. The hypothalamic - pituitary - gonadal axis and sex hormones also have an important immunoregulatory role. The immune system signals the CNS through immune mediators and cytokines that can cross the blood - brain barrier, or signal indirectly through the vagus nerve or second messengers. Neuroendocrine regulation of immune function is essential for survival during stress or infection and to modulate immune responses in inflammatory disease. This review discusses neuroimmune interactions and evidence for the role of such neural immune regulation of inflammation, rather than a discussion of the individual inflammatory mediators, in rheumatoid arthritis.
引用
收藏
页码:251 / 265
页数:15
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