The Toll-IL-1 receptor adaptor family grows to five members

被引：384

作者：

O'Neill, LAJ ^{[1
]}

Fitzgerald, KA

Bowie, AG

机构：

[1] Trinity Coll Dublin, Dept Biochem, Cytokine Res Grp, Dublin, Ireland

[2] Univ Massachusetts, Sch Med, Div Infect Dis & Immunol, Worcester, MA 01605 USA

[3] Trinity Coll Dublin, Dept Biochem, Viral Immune Evas Grp, Dublin, Ireland

来源：

TRENDS IN IMMUNOLOGY | 2003年 / 24卷 / 06期

关键词：

D O I：

10.1016/S1471-4906(03)00115-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Toll-like receptor (TLR) signal transduction is mediated by an adaptor protein termed MyD88. In the case of TLR2 and TLR4, another adaptor related to MyD88 called Mal also participates in signalling. Two recent papers have added a third adaptor to the family, called Toll-interleukin-1 receptor (TIR) domain-containing adaptor inducing interferon-beta (IFN-beta) (TRIF) or TIR-containing adaptor molecule-1 (TICAM-1), which is particularly important for IFN regulatory factor-3 (IRF-3) activation by antiviral TLR3. Two additional adaptors are present in humans, termed Trif-related adaptor molecule (TRAM) and sterile a and HEAT-Armadillo motifs (SARM). It is probable that differential use of adaptors will help explain the distinct pathways activated by TLRs during host defence.

引用

页码：287 / 290

页数：4

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