Natural regulatory T cells in infectious disease

被引：812

作者：

Belkaid, Y

Rouse, BT

机构：

[1] Cincinnati Childrens Hosp Res Fdn, Div Mol Immunol, Cincinnati, OH 45229 USA

[2] Univ Tennessee, Dept Microbiol, Knoxville, TN 37996 USA

来源：

NATURE IMMUNOLOGY | 2005年 / 6卷 / 04期

关键词：

D O I：

10.1038/ni1181

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This review discusses the control exerted by natural CD4(+)CD25(+) regulatory T cells ( natural T-reg cells) during infectious processes. Natural T-reg cells may limit the magnitude of effector responses, which may result in failure to adequately control infection. However, natural T-reg cells also help limit collateral tissue damage caused by vigorous antimicrobial immune responses. We describe here various situations in which the balance between natural T-reg cells and effector immune functions influences the outcome of infection and discuss how manipulating this equilibrium might be exploited therapeutically.

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收藏

页码：353 / 360

页数：8

相关论文

共 82 条

[1] Human CD4+ CD25+ regulatory T cells control T-cell responses to human immunodeficiency virus and cytomegalovirus antigens [J].

Aandahl, EM ;

Michaëlsson, J ;

Moretto, WJ ;

Hecht, FA ;

Nixon, DF .

JOURNAL OF VIROLOGY, 2004, 78 (05) :2454-2459

[2] Cutting edge: The prevalence of regulatory T cells lymphoid tissue is correlated with viral load HIV-infected patients [J].

Andersson, J ;

Boasso, A ;

Nilsson, J ;

Zhang, R ;

Shire, NJ ;

Lindback, S ;

Shearer, GM ;

Chougnet, CA .

JOURNAL OF IMMUNOLOGY, 2005, 174 (06) :3143-3147

[3] The early IL-4 response to Leishmania major and the resulting Th2 cell maturation steering progressive disease in BALB/c mice are subject to the control of regulatory CD4+CD25+ T cells [J].

Aseffa, A ;

Gumy, A ;

Launois, P ;

MacDonald, HR ;

Louis, JA ;

Tacchini-Cottier, F .

JOURNAL OF IMMUNOLOGY, 2002, 169 (06) :3232-3241

[4] Timed ablation of regulatory CD4+ T cells can prevent murine AIDS progression [J].

Beilharz, MW ;

Sammels, LM ;

Paun, A ;

Shaw, K ;

van Eeden, P ;

Watson, MW ;

Ashdown, ML .

JOURNAL OF IMMUNOLOGY, 2004, 172 (08) :4917-4925

[5] TGF-β-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes [J].

Belghith, M ;

Bluestone, JA ;

Barriot, S ;

Mégret, J ;

Bach, JF ;

Chatenoud, L .

NATURE MEDICINE, 2003, 9 (09) :1202-1208

[6] A natural model of Leishmania major infection reveals a prolonged "silent" phase of parasite amplification in the skin before the onset of lesion formation and immunity [J].

Belkaid, Y ;

Mendez, S ;

Lira, R ;

Kadambi, N ;

Milon, G ;

Sacks, D .

JOURNAL OF IMMUNOLOGY, 2000, 165 (02) :969-977

[7] CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity [J].

Belkaid, Y ;

Piccirillo, CA ;

Mendez, S ;

Shevach, EM ;

Sacks, DL .

NATURE, 2002, 420 (6915) :502-507

[8] The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure [J].

Belkaid, Y ;

Hoffmann, KF ;

Mendez, S ;

Kamhawi, S ;

Udey, MC ;

Wynn, TA ;

Sacks, DL .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (10) :1497-1506

[9] Natural versus adaptive regulatory T cells [J].

Bluestone, JA ;

Abbas, AK .

NATURE REVIEWS IMMUNOLOGY, 2003, 3 (03) :253-257

[10] CD4+CD25+ regulatory T-cell deficiency in patients with hepatitis C-mixed cryoglobulinemia vasculitis [J].

Boyer, O ;

Saadoun, D ;

Abriol, J ;

Dodille, M ;

Piette, JC ;

Cacoub, P ;

Klatzmann, D .

BLOOD, 2004, 103 (09) :3428-3430

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