Circadian rhythm and the per ACNGGN repeat in the mole rat, Spalax ehrenbergi

被引：10

作者：

BenShlomo, R

Ritte, U

Nevo, E

机构：

[1] UNIV HAIFA, INST EVOLUT, IL-31905 HAIFA, ISRAEL

[2] HEBREW UNIV JERUSALEM, DEPT GENET, IL-91904 JERUSALEM, ISRAEL

来源：

BEHAVIOR GENETICS | 1996年 / 26卷 / 02期

关键词：

subterranean mole rats; Spalax ehrenbergi; circadian rhythm; Drosophila period gene; ACNGGN repeat sequence; restriction fragment length polymorphism;

D O I：

10.1007/BF02359895

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Individual variability in circadian locomotor activity has recently been discovered in the blind mole rat, Spalax ehrenbergi. An interesting association was found between different circadian activity types and two DNA fragments, 5.6 and 5.9 kb long, that contain the ACNGGN repeat sequence, homologous to a part of the period gene of Drosophila. Nine of 12 arrythmic animals showed the 5.6-kb band, while 13 of 17 circadian rhythmic animals had the 5.9-kb band. This repeat exists also in the brain RNA of the mole rat, apparently in higher quantities during the sleeping phase, suggesting that an unusual protein(s), composed of a poly-Thr-Gly segment, affects its circadian rhythm.

引用

页码：177 / 184

页数：8

共 35 条

[1] CHANGES IN ABUNDANCE OR STRUCTURE OF THE PER GENE-PRODUCT CAN ALTER PERIODICITY OF THE DROSOPHILA CLOCK [J].