Intracellular delivery of large molecules and small particles by cell-penetrating proteins and peptides

被引：509

作者：

Gupta, B ^{[1
]}

Levchenko, TS ^{[1
]}

Torchilin, VP ^{[1
]}

机构：

[1] Northeastern Univ, Dept Pharmaceut Sci, Bouve Coll Hlth Sci, Boston, MA 02115 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2005年 / 57卷 / 04期

关键词：

intracellular delivery; cell-penetrating peptides; fusion proteins; gene delivery; toxins; imaging agents; particles; liposomes;

D O I：

10.1016/j.addr.2004.10.007

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cell-penetrating peptides (CPPs) have been used to overcome the lipophilic barrier of the cellular membranes and deliver large molecules and even small particles inside the cell for their biological actions. CPPs are being used to deliver inside cell a large variety of cargoes such as proteins, DNA, antibodies, contrast (imaging) agents, toxins, and nanoparticular drug carriers including liposomes. In this paper, we have reviewed the delivery of different molecules and particles mediated by TAT, Antp, VP22, and other CPPs as well as potential applications of these delivery systems in different areas of vaccine development, cancer immunotherapy, gene delivery, and cellular imaging. (c) 2004 Elsevier B.V All rights reserved.

引用

页码：637 / 651

页数：15

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