Baclofen inhibits opiate-induced conditioned place preference and associated induction of Fos in cortical and limbic regions

被引：36

作者：

Kaplan, GB ^{[1
]}

Leite-Morris, KA

Joshi, M

Shoeb, MH

Carey, RJ

机构：

[1] Vet Affairs Med Ctr, Mental Hlth Serv, Providence, RI 02908 USA

[2] Vet Adm Med Ctr, Res Serv, Providence, RI 02908 USA

[3] Brown Med Sch, Dept Psychiat & Human Behav, Providence, RI 02912 USA

[4] Brown Med Sch, Dept Mol Pharmacol, Providence, RI 02912 USA

[5] Brown Med Sch, Dept Physiol, Providence, RI 02912 USA

[6] Brown Med Sch, Dept Biotechnol, Providence, RI 02912 USA

[7] Brown Med Sch, Ctr Alcohol & Addict Studies, Providence, RI 02912 USA

[8] Vet Adm Med Ctr, Res Serv, Syracuse, NY 13210 USA

来源：

BRAIN RESEARCH | 2003年 / 987卷 / 01期

关键词：

opiate; conditioning; reward; gamma-aminobutyric acid; dopamine;

D O I：

10.1016/S0006-8993(03)03218-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In C57BL/6 mice, pretreatment with GABA(B) receptor agonist baclofen blocked the rewarding effects of morphine as measured by acquisition of conditioned place preference. Fos immunoreactivity, a neuronal activity marker, was induced in opiate conditioned mice in several forebrain regions including the nucleus accumbens core and shell, anterior cingulate cortex, and prelimbic cortex. Baclofen pretreatment blocked the induction of Fos in opiate conditioned subjects. These result suggest that GABA(B) receptor transmission has a role in reversing morphine-induced activation of motivational circuitry and conditioned reward. Published by Elsevier B.V.

引用

页码：122 / 125

页数：4

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