Activation of EGFR and ERK by rhomboid signaling regulates the consolidation and maintenance of sleep in Drosophila

被引：186

作者：

Foltenyi, Krisztina

Greenspan, Ralph J.

Newport, John W.

机构：

[1] Inst Neurosci, San Diego, CA 92121 USA

[2] Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA

来源：

NATURE NEUROSCIENCE | 2007年 / 10卷 / 09期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1038/nn1957

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Epidermal growth factor receptor ( EGFR) signaling in the mammalian hypothalamus is important in the circadian regulation of activity. We have examined the role of this pathway in the regulation of sleep in Drosophila melanogaster. Our results demonstrate that rhomboid ( Rho)- and Star-mediated activation of EGFR and ERK signaling increases sleep in a dose-dependent manner, and that blockade of rhomboid ( rho) expression in the nervous system decreases sleep. The requirement of rho for sleep localized to the pars intercerebralis, a part of the fly brain that is developmentally and functionally analogous to the hypothalamus in vertebrates. These results suggest that sleep and its regulation by EGFR signaling may be ancestral to insects and mammals.

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页码：1160 / 1167

页数：8

相关论文

共 51 条

[1] Dopaminergic modulation of arousal in Drosophila [J].

Andretic, R ;

van Swinderen, B ;

Greenspan, RJ .

CURRENT BIOLOGY, 2005, 15 (13) :1165-1175

[2]

Basyuk E, 2000, Nucleic Acids Res, V28, pE46, DOI 10.1093/nar/28.10.e46

[3] Deregulation of the Egfr/Ras signaling pathway induces age-related brain degeneration in the Drosophila mutant vap [J].

Botella, JA ;

Kretzschmar, D ;

Kiermayer, C ;

Feldmann, P ;

Hughes, DA ;

Schneuwly, S .

MOLECULAR BIOLOGY OF THE CELL, 2003, 14 (01) :241-250

[4]

BRAND AH, 1993, DEVELOPMENT, V118, P401

[5] Reduced sleep in Drosophila shaker mutants [J].

Cirelli, C ;

Bushey, D ;

Hill, S ;

Huber, R ;

Kreber, R ;

Ganetzky, B ;

Tononi, G .

NATURE, 2005, 434 (7037) :1087-1092

[6] Embryonic development of the Drosophila corpus cardiacum, a neuroendocrine gland with similarity to the vertebrate pituitary, is controlled by sine oculis and glass [J].

De Velasco, B ;

Shen, J ;

Go, S ;

Hartenstein, V .

DEVELOPMENTAL BIOLOGY, 2004, 274 (02) :280-294

[7] Specification and development of the pars intercerebralis and pars lateralis, neuroendocrine command centers in the Drosophila brain [J].

de Velasco, Begona ;

Erclik, Ted ;

Shy, Diana ;

Sclafani, Joey ;

Lipshitz, Howard ;

McInnes, Roderick ;

Hartenstein, Volker .

DEVELOPMENTAL BIOLOGY, 2007, 302 (01) :309-323

[8] Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye [J].

Freeman, M .

CELL, 1996, 87 (04) :651-660

[9] The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses [J].

Garcia, RAG ;

Vasudevan, K ;

Buonanno, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (07) :3596-3601

[10] A screen for dominant mutations applied to components in the Drosophila EGF-R pathway [J].

Guichard, A ;

Srinivasan, S ;

Zimm, G ;

Bier, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (06) :3752-3757

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