The prolyl isomerase PIN 1: a pivotal new twist in phosphorylation signalling and disease

被引：592

作者：

Lu, Kun Ping ^{[1
]}

Zhou, Xiao Zhen ^{[1
]}

机构：

[1] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Med,Div Hematol Oncol,Canc Biol Program, Boston, MA 02215 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2007年 / 8卷 / 11期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm2261

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Protein phosphorylation regulates many cellular processes by causing changes in protein conformation. The prolyl isomerase PIN1 has been identified as a regulator of phosphorylation signalling that catalyses the conversion of specific phosphorylated motifs between the two completely distinct conformations in a subset of proteins. PIN 1 regulates diverse cellular processes, including growth-signal responses, cell-cycle progression, cellular stress responses, neuronal function and immune responses. In line with the diverse physiological roles of PIN1, it has also been linked to several diseases that include cancer, Alzheimer's disease and asthma, and thus it might represent a novel therapeutic target.

引用

页码：904 / 916

页数：13

共 149 条

[1] Pin1 promotes production of Alzheimer's amyloid from β-cleaved amyloid precursor protein [J].