Synthesis and biological activity of some antitumor active derivatives from glycyrrhetinic acid

被引：88

作者：

Csuk, Rene ^{[1
]}

Schwarz, Stefan ^{[1
]}

Kluge, Ralph ^{[1
]}

Stroehl, Dieter ^{[1
]}

机构：

[1] Univ Halle Wittenberg, Bereich Organ Chem, D-06120 Halle, Saale, Germany

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 12期

关键词：

Glycyrrhetinic acid; Antitumor activity; Apoptosis; LEUKEMIA-CELLS; DOWN-REGULATION; CANCER CELLS; APOPTOSIS; INDUCTION; PATHWAY; INHIBITION; TOXICITY; EXTRACTS; FLIP;

D O I：

10.1016/j.ejmech.2010.09.028

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Aminoalkyl substituted derivatives were synthesized starting from glycyrrhetinic acid methyl ester and screened for antitumor activity in a panel of 15 human cancer cell lines by an SRB assay. The most compound 7 possesses an aminohexyl side chain, induces apoptosis and shows IC(50) values of 0.6-3.0 mu M. (C) 2010 Elsevier Masson SAS. All rights reserved.

引用

页码：5718 / 5723

页数：6

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