Immune response to Fusobacterium nucleatum and Prevotella intermedia in the sputum of patients with acute exacerbation of chronic bronchitis

被引：46

作者：

Brook, I ^{[1
]}

Frazier, EH ^{[1
]}

机构：

[1] Natl Naval Med Ctr, Bethesda, MD USA

来源：

CHEST | 2003年 / 124卷 / 03期

关键词：

acute exacerbation of chronic bronchitis; Fusobacterium spp; immune response; Prevotella spp;

D O I：

10.1378/chest.124.3.832

中图分类号：

R4 [临床医学];

学科分类号：

1002 [临床医学]; 100602 [中西医结合临床];

摘要：

Objective: To assess the role of anaerobic bacteria in acute exacerbation of chronic bronchitis (AECB). Methods: The level of the Ig-A class to two organisms (Fusobacterium nucleatum and Prevotella intermedia) was determined in the sputum of 25 patients with AECB and 25 control patients. The presence and level of these antibodies were investigated by enzyme-linked immunosorbent assay. Results: The median sputum antibody level for F nucleatum and P intermedia were significantly higher in patients with AECB as compared to control patients (p < 0.05). The IgA levels for F nucleatum was 3.5 times higher in patients with AECB and 3.8 times greater for P intermedia. Conclusions: This study demonstrates for the first time an elevated sputum antibody titers in patients with AECB to F nucleatum and P intermedia.

引用

页码：832 / 833

页数：2

共 11 条

[1]

[Anonymous], 1987, AM REV RESPIR DIS, V136, P225

[2]

Systemic and mucosal antibody response to Moraxella catarrhalis after exacerbations of chronic obstructive pulmonary disease [J].