Polymer micelle with cross-linked ionic core

被引:217
作者
Bronich, TK
Keifer, PA
Shlyakhtenko, LS
Kabanov, AV
机构
[1] Univ Nebraska, Med Ctr, Dept Pharmaceut Sci, Omaha, NE 68198 USA
[2] Univ Nebraska, Med Ctr, Eppley Inst Res Canc, Omaha, NE 68198 USA
关键词
D O I
10.1021/ja043042m
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
This work reports the design of polymer micelles with cross-linked ionic cores that display high stability. Block ionomer complexes were utilized as a micellar template for the synthesis of the cross-linked micelles. Such micelles represent hydrophilic nanospheres of core-shell morphology. The core comprises a network of the cross-linked polyanions, which is surrounded by the shell of hydrophilic PEO chains. Copyright © 2005 American Chemical Society.
引用
收藏
页码:8236 / 8237
页数:2
相关论文
共 17 条
[1]  
[Anonymous], 1980, METAL IONS BIOL SYST
[2]   Dependency of swelling on the length of subchain in poly(N,N-dimethylacrylamide)-based gels [J].
Bromberg, L ;
Grosberg, AY ;
Matsuo, ES ;
Suzuki, Y ;
Tanaka, T .
JOURNAL OF CHEMICAL PHYSICS, 1997, 106 (07) :2906-2910
[3]   Soluble complexes from poly(ethylene oxide)-block-polymethacrylate anions and N-alkylpyridinium cations [J].
Bronich, TK ;
Kabanov, AV ;
Kabanov, VA ;
Yu, K ;
Eisenberg, A .
MACROMOLECULES, 1997, 30 (12) :3519-3525
[4]   CONFORMATIONS OF POLYMERS ATTACHED TO AN INTERFACE [J].
DEGENNES, PG .
MACROMOLECULES, 1980, 13 (05) :1069-1075
[5]   Macromolecular therapeutics - Advantages and prospects with special emphasis on solid tumour targeting [J].
Greish, K ;
Fang, J ;
Inutsuka, T ;
Nagamitsu, A ;
Maeda, H .
CLINICAL PHARMACOKINETICS, 2003, 42 (13) :1089-1105
[6]   FORMATION OF POLYION COMPLEX MICELLES IN AN AQUEOUS MILIEU FROM A PAIR OF OPPOSITELY-CHARGED BLOCK-COPOLYMERS WITH POLY(ETHYLENE GLYCOL) SEGMENTS [J].
HARADA, A ;
KATAOKA, K .
MACROMOLECULES, 1995, 28 (15) :5294-5299
[7]   Hydrogel-coated glassy nanospheres: A novel method for the synthesis of shell cross-linked knedels [J].
Huang, HY ;
Kowalewski, T ;
Remsen, EE ;
Gertzmann, R ;
Wooley, KL .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (48) :11653-11659
[8]   Enhancing drug function [J].
Hubbell, JA .
SCIENCE, 2003, 300 (5619) :595-596
[9]   Pluronic® block copolymers in drug delivery:: From micellar nanocontainers to biological response modifiers [J].
Kabanov, AV ;
Alakhov, VY .
CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS, 2002, 19 (01) :1-72
[10]   WATER-SOLUBLE BLOCK POLYCATIONS AS CARRIERS FOR OLIGONUCLEOTIDE DELIVERY [J].
KABANOV, AV ;
VINOGRADOV, SV ;
SUZDALTSEVA, YG ;
ALAKHOV, VY .
BIOCONJUGATE CHEMISTRY, 1995, 6 (06) :639-643