Griffonianone D, an isoflavone with anti-inflammatory activity from the root bark of Millettia griffoniana

被引：33

作者：

Yankep, E

Njamen, D

Fotsing, MT

Fomum, ZT

Mbanya, JC

Giner, RM

Recio, MC

Máñez, S

Ríos, JL

机构：

[1] Univ Yaounde 1, Fac Sci, Dept Organ Chem, Yaounde, Cameroon

[2] Univ Yaounde 1, Fac Sci, Dept Anim Biol & Physiol, Physiol Anim Lab, Yaounde, Cameroon

[3] Univ Yaounde, Fac Med & Biomed Sci, Dept Internal Med, Yaounde, Cameroon

[4] Univ Valencia, Fac Farm, Dept Farmacol, E-46100 Valencia, Spain

来源：

JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 09期

关键词：

D O I：

10.1021/np0205912

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new isoflavone, griffonianone D (1), and the previously known compounds durmillone and odorantin were isolated from a chloroform extract of the root bark of Millettia griffoniana. The structure of 1 was established as (7E)-(6",7"-dihydroxy-3",7"-dimethyloct-2"-enyl)oxy-4'-methoxyisoflavone on the basis of its spectral data. The chloroform extract of the root bark of M. griffoniana and compound 1 showed anti-inflammatory effects in different experimental models of inflammation.

引用

页码：1288 / 1290

页数：3

共 18 条

[1] Formation of novel bioactive metabolites from the reactions of pro-inflammatory oxidants with polyphenolics [J].