Regulation of life span by mitochondrial respiration: the HIF-1 and ROS connection

被引：79

作者：

Hwang, Ara B. ^{[1
]}

Lee, Seung-Jae ^{[1
,2
,3
]}

机构：

[1] Pohang Univ Sci & Technol, Div Mol & Life Sci, Pohang 790784, Kyungbuk, South Korea

[2] Pohang Univ Sci & Technol, Sch Interdisciplinary Biosci & Bioengn, Pohang 790784, Kyungbuk, South Korea

[3] Pohang Univ Sci & Technol, World Class Univ Informat Technol Convergence Eng, Pohang 790784, Kyungbuk, South Korea

来源：

AGING-US | 2011年 / 3卷 / 03期

关键词：

NEMATODE CAENORHABDITIS-ELEGANS; OXIDATIVE STRESS; C-ELEGANS; ELECTRON-TRANSPORT; ENERGY-METABOLISM; COMPLEX-III; STEM-CELLS; HYPOXIA; MUTANTS; DYSFUNCTION;

D O I：

10.18632/aging.100292

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A mild reduction in mitochondrial respiration extends the life span of many species, including C. elegans. We recently showed that hypoxia-inducible factor 1 (HIF-1) is required for the acquisition of a long life span by mutants with reduced respiration in C. elegans. We suggested that increased levels of reactive oxygen species (ROS) produced in the respiration mutants increase HIF-1 activity and lead to this longevity. In this research perspective, we discuss our findings and recent advances regarding the roles of ROS and HIF-1 in aging, focusing on the longevity caused by reduced respiration.

引用

页码：304 / 310

页数：7

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