Involvement of aspirin-sensitive oxylipins in vulvovaginal candidiasis

被引:54
作者
Deva, R
Ciccoli, R
Kock, L
Nigam, S
机构
[1] Free Univ Berlin, Klinikum Benjamin Franklin, Dept Gynecol & Obstet, Eicosanoid Res Div, D-12200 Berlin, Germany
[2] Univ Free State, Dept Microbiol & Biochem, Bloemfontein, South Africa
关键词
vulvovaginal candidiasis; 3(R)-hydroxyoxylipin; acetysalicylic acid; clotrimazole; immunofluorescence microscopy; Candida albicans;
D O I
10.1111/j.1574-6968.2001.tb10616.x
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
3(R)-Hydroxyoxylipins are produced via an aspirin-sensitive pathway in Candida albicans, an abundant pathogen in vulvovaginal candidiasis. In the present study, we have investigated the effect of aspirin on vaginal isolates of C. albicans from patients with recurrent candidiasis. Aspirin alone and with clotrimazole. a commonly used drug, strongly suppressed growth of C. albicans. 3(R)-Hydroxyoxylipins, which were selectively located in hyphae and other filamentous structures, but not in free blastospores, were almost totally suppressed by aspirin. Moreover, C. albicans stimulated prostaglandin E-2 (PGE(2)) production in HeLa cells. PGE(2) is a stimulus for germ tube formation in C, albicans. We conclude therefore that the administration of aspirin should be beneficial in the treatment of vulvovaginal candidiasis by dual ways: (i) by inhibition of 3(R)-hydroxyoxylipin formation, and (ii) by inhibition of PGE(2) formation in the infected host tissue. (C) 2001 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
引用
收藏
页码:37 / 43
页数:7
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