Activation of GABAA receptors:: Views from outside the synaptic cleft

被引：255

作者：

Glykys, Joseph ^{[3
]}

Mody, Istvan ^{[1
,2
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Physiol, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Interdept PhD Program Neurosci, Los Angeles, CA 90095 USA

来源：

NEURON | 2007年 / 56卷 / 05期

关键词：

D O I：

10.1016/j.neuron.2007.11.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Some GABA(A) receptors (GABA(A)Rs) are activated by low transmitter levels present in the extracellular space and generate an uninterrupted conductance referred to as "tonic." This tonic conductance is highly sensitive to all factors regulating the amount of GABA surrounding the neurons. Only a few GABAARs with particular subunit combinations are well suited to mediate the tonic conductance. These same receptors constitute important and specific targets for various endogenous and exogenous neuroactive compounds and possible therapeutic targets.

引用

页码：763 / 770

页数：8

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