Cerebral cortical blood flow during loss of consciousness induced by gravitational stress in rhesus monkeys

被引：7

作者：

Florence, G ^{[1
]}

Bonnier, R ^{[1
]}

Riondet, L ^{[1
]}

Plagnes, D ^{[1
]}

Lagarde, D ^{[1
]}

Van Beers, P ^{[1
]}

Serra, A ^{[1
]}

Etienne, X ^{[1
]}

Tran, D ^{[1
]}

机构：

[1] Dept Phys Aerospatiale, Serv St Armees, Inst Med Aerospatiale, F-91223 Bretigny Orge, France

来源：

NEUROSCIENCE LETTERS | 2001年 / 305卷 / 02期

关键词：

acceleration; cerebral perfusion; syncope; laser-Doppler;

D O I：

10.1016/S0304-3940(01)01818-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated the influence of +G(z) acceleration (head-to-foot inertial forces) onset on cerebral cortical blood flow (CBF) of rhesus monkeys to study the mechanisms underlying +G(z)-induced loss of consciousness (G-LOC). CBF was measured through a chronic cranial window by laser-Doppler flowmetry and electrodes in contact with the dura mater were used to detect G-LOC (suppression of the cortical electrical activity). The animals were centrifuged up to +12 G(z) with different G-onset rate until G-LOC occurred. G-LOC was preceded by a 2-5 s decrease in CBF. At G-LOC detection, CBF was not related to G-onset rate (mean CBF change: -76 +/- 9% of control value). We conclude that G-LOC results from cerebral ischemia rather than from mechanical stresses applied to the brain. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：99 / 102

页数：4

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