Ventroptin: A BMP-4 antagonist expressed in a double-gradient pattern in the retina

被引：163

作者：

Sakuta, H

Suzuki, R

Takahashi, H

Kato, A

Shintani, T

Iemura, S

Yamamoto, TS

Ueno, N

Noda, M

机构：

[1] Grad Univ Adv Studies, Natl Inst Basic Biol, Div Mol Neurobiol, Okazaki, Aichi 4448585, Japan

[2] Grad Univ Adv Studies, Natl Inst Basic Biol, Div Morphogenesis, Okazaki, Aichi 4448585, Japan

[3] Grad Univ Adv Studies, Dept Mol Biomech, Okazaki, Aichi 4448585, Japan

来源：

SCIENCE | 2001年 / 293卷 / 5527期

关键词：

D O I：

10.1126/science.1058379

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In the visual system, the establishment of the anteroposterior and dorsoventral axes in the retina ana tectum during development is important for topographic retinotectal projection. We identified chick Ventroptin, an antagonist of bone morphogenetic protein 4 (BMP-4), which is mainly expressed in the ventral retina, not only with a ventral high-dorsal low gradient but also with a nasal high-temporal Low gradient at later stages, Misexpression of Ventroptin altered expression patterns of several topographic genes in the retina and projection of the retinal axons to the tectum along both axes. Thus, the topographic retinotectal projection appears to be specified by the double-gradient molecule Ventroptin along the two axes.

引用

页码：111 / 115

页数：5

共 20 条

[1] Is chordin a long-range- or short-range-acting factor?: Roles for BMP1-related metalloproteases in chordin and BMP4 autofeedback loop regulation [J].