Study of tobacco smoke influence on content of estrogens and DNA flow cytometry data in uterine tissue of rats of different age

被引：4

作者：

Berstein, LM ^{[1
]}

Tsyrlina, EV ^{[1
]}

Gamajunova, VB ^{[1
]}

Bychkova, NV ^{[1
]}

Krjukova, OG ^{[1
]}

Dzhumasultanova, SV ^{[1
]}

Kovalenko, IG ^{[1
]}

Kolesnik, OS ^{[1
]}

机构：

[1] NN Petrov Oncol Res Inst, Lab Oncoendocrinol, St Petersburg 189646, Russia

来源：

HORMONE AND METABOLIC RESEARCH | 1999年 / 31卷 / 01期

关键词：

estrogens; uterus; age; DNA; proliferation; tobacco smoke;

D O I：

10.1055/s-2007-978692

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Female rats aged 2.5-3 months ("young") and 6 months ("adult") were or were not exposed to the influence of tobacco smoke (mainstream cigarette smoke, 2 hrs/day during 3 weeks or 3 months). Treatment with tobacco smoke did not induce any changes in uterine weight or estrous cycle but led to the decrease of estradiol (E-2) concentration in uterine tissue (especially in adult rats or in young rats after 3 months of experiment). No signs of aneuploidy were found in uteruses of animals-"smokers" though proliferation index and percentage of cells in S-phase were increased (according to flow cytometry data) by 3 weeks and decreased by 3 months of experiment. The data obtained support previously made assumption pointing to phasic character of changes in reproductive system under the influence of tobacco smoke and may be used for further confirmation of the concept explaining the role of smoking in the shift of hormonal (estrogen-induced) carcinogenesis type from promotional to genotoxic one.

引用

页码：27 / 30

页数：4

共 14 条

[1] CIGARETTE-SMOKING AND NEOPLASMS OF THE FEMALE REPRODUCTIVE-TRACT AND BREAST [J].

BARON, JA ;

GREENBERG, ER .

SEMINARS IN REPRODUCTIVE ENDOCRINOLOGY, 1989, 7 (04) :335-343

[2]

Bershtein L M, 1997, Ross Fiziol Zh Im I M Sechenova, V83, P84

[3] Influence of tobacco smoke on DNA unwinding and uterotrophic effect of estrogens in rats [J].

Berstein, LM ;

Tsyrlina, EV ;

Krjukova, OG ;

Dzhumasultanova, SV .

CANCER LETTERS, 1998, 127 (1-2) :95-98

[4]

Berstein LM, 1996, CANCER J - FRANCE, V9, P106

[5]

BERSTEIN LM, 1995, ONCOENDOCRINOLOGY SM, P127

[6] AROMATASE-ACTIVITY AND ESTRADIOL IN HUMAN BREAST-CANCER - ITS RELATIONSHIP TO ESTRADIOL AND EPIDERMAL GROWTH-FACTOR RECEPTORS AND TO TUMOR-NODE-METASTASIS STAGING [J].

BOLUFER, P ;

RICART, E ;

LLUCH, A ;

VAZQUEZ, C ;

RODRIGUEZ, A ;

RUIZ, A ;

LLOPIS, F ;

GARCIACONDE, J ;

ROMERO, R .

JOURNAL OF CLINICAL ONCOLOGY, 1992, 10 (03) :438-446

[7]

Bychkova N V, 1996, Vopr Onkol, V42, P57

[8]

GAIROLA CG, 1997, P 7 C INT ASS BIOM G, P65

[9] IN-VIVO INDUCTION OF INCREASED DNA-PLOIDY OF MOUSE CERVICOVAGINAL EPITHELIUM BY NEONATAL ESTROGEN-TREATMENT [J].

HAJEK, RA ;

VAN, NT ;

JOHNSTON, DA ;

JONES, LA .

BIOLOGY OF REPRODUCTION, 1993, 49 (05) :908-917

[10] TOBACCO ALKALOID DERIVATIVES AS INHIBITORS OF BREAST-CANCER AROMATASE [J].

KADOHAMA, N ;

SHINTANI, K ;

OSAWA, Y .

CANCER LETTERS, 1993, 75 (03) :175-182

← 1 2 →