Impact of human Metapneumovirus and Respiratory Syncytial Virus co-infection in severe bronchiolitis

被引：24

作者：

McNamara, Paul S.

Flanagan, Brian F.

Smyth, Rosalind L.

Hart, C. Anthony

机构：

[1] Royal Liverpool Childrens Hosp, Inst Child Hlth, Liverpool L12 2AP, Merseyside, England

[2] Univ Liverpool, Dept Med Microbiol, Liverpool L69 3GA, Merseyside, England

[3] Univ Liverpool, Dept Immunol, Liverpool L69 3BX, Merseyside, England

来源：

PEDIATRIC PULMONOLOGY | 2007年 / 42卷 / 08期

基金：

英国惠康基金;

关键词：

bronchiolitis; infant; respiratory syncytial virus; human metapneumovirus; cytokines;

D O I：

10.1002/ppul.20649

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We have previously shown high rates of co-infection with Respiratory Syncytial Virus (RSV) and human Metapneumovirus (hMPV) in infants with severe bronchiolitis at our institution in 2000-2002, and that co-infection was associated with increased disease severity In this study, we have attempted to identify differences in intubated infants with severe RSV infection with and without hMPV co-infection. Here we show that RSV+/hMPV+ were clinically symptomatic for longer than RSV+/hMPV- infants, but that no differences in airway total cell concentration, differential cell count or cytokine/chemokine concentrations were detectable.

引用

收藏

页码：740 / 743

页数：4

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