Characterization and Inhibition of a cholecystokinin-inactivating serine peptidase

被引：140

作者：

Rose, C

Vargas, F

Facchinetti, P

Bourgeat, P

Bambal, RB

Bishop, PB

Chan, SMT

Moore, ANJ

Ganellin, CR

Schwartz, JC

机构：

[1] UNIV LONDON UNIV COLL, CHRISTOPHER INGOLD LABS, DEPT CHEM, LONDON WC1H 0AJ, ENGLAND

[2] UNIV PARIS 05, FAC PHARM, F-75006 PARIS, FRANCE

来源：

NATURE | 1996年 / 380卷 / 6573期

关键词：

D O I：

10.1038/380403a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A cholecystokinin (CCK)-inactivating peptidase was purified and identified as a membrane-bound isoform of tripeptidyl peptidase II (EC 3.4. 14. 10), a cytosolic subtilisin-like peptidase of previously unknown functions. The peptidase was found in neurons responding to cholecystokinin, as well as in non-neuronal cells. Butabindide, a potent and specific inhibitor, was designed and shown to protect endogenous cholecystokinin from inactivation and to display pro-satiating effects mediated by the CCKA receptor.

引用

页码：403 / 409

页数：7

共 50 条

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BALOW RM, 1983, J BIOL CHEM, V258, P1622

[2]

BALOW RM, 1986, J BIOL CHEM, V261, P2409

[3] EFFECTS OF ACETORPHAN, AN ENKEPHALINASE INHIBITOR, ON EXPERIMENTAL AND ACUTE DIARRHEA [J].