Ontogeny and function of murine epidermal Langerhans cells

被引：105

作者：

Kaplan, Daniel H. ^{[1
,2
]}

机构：

[1] Univ Pittsburgh, Dept Dermatol, Pittsburgh, PA 15260 USA

[2] Univ Pittsburgh, Dept Immunol, Pittsburgh, PA 15260 USA

来源：

NATURE IMMUNOLOGY | 2017年 / 18卷 / 10期

基金：

美国国家卫生研究院;

关键词：

DERMAL DENDRITIC CELLS; REGULATORY T-CELLS; ALLERGIC CONTACT-DERMATITIS; STEADY-STATE CONDITIONS; IN-VIVO; IMMUNE-RESPONSES; TISSUE-RESIDENT; TGF-BETA; AUTOCRINE/PARACRINE TGF-BETA-1; ATOPIC-DERMATITIS;

D O I：

10.1038/ni.3815

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Langerhans cells (LCs) are epidermis-resident antigen-presenting cells that share a common ontogeny with macrophages but function as dendritic cells (DCs). Their development, recruitment and retention in the epidermis is orchestrated by interactions with keratinocytes through multiple mechanisms. LC and dermal DC subsets often show functional redundancy, but LCs are required for specific types of adaptive immune responses when antigen is concentrated in the epidermis. This Review will focus on those developmental and functional properties that are unique to LCs.

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收藏

页码：1068 / 1075

页数：8

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