Basic helix-loop-helix factors in cortical development

被引:524
作者
Ross, SE
Greenberg, ME
Stiles, CD
机构
[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Microbiol & Mol Genet, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Childrens Hosp, Dept Neurobiol,Div Neurosci, Boston, MA 02115 USA
关键词
D O I
10.1016/S0896-6273(03)00365-9
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Transcription factors with bHLH motifs modulate critical events in the development of the mammalian neocortex. Multipotent cortical progenitors are maintained in a proliferative state by bHLH factors from the Id and Hes families. The transition from proliferation to neurogenesis involves a coordinate increase in the activity of proneural bHLH factors (Mash1, Neurogenin1,, and Neurogenin2) and a decrease in the activity of Hes and Id factors. As development proceeds, inhibition of proneural bHLH factors in cortical progenitors promotes the formation of astrocytes. Finally, the formation of oligodendrocytes is triggered by an increase in the activity of bHLH factors Olig1 and Olig2 that may be coupled with a decrease in Id activity. Thus, bHLH factors have key roles in corticogenesis, affecting the timing of differentiation and the specification of cell fate.
引用
收藏
页码:13 / 25
页数:13
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