Cannabinoid agonists and antagonists modulate lithium-induced conditioned gaping in rats

被引：39

作者：

Parker, LA ^{[1
]}

Mechoulam, R

机构：

[1] Wilfrid Laurier Univ, Dept Psychol, Waterloo, ON N2L 3C5, Canada

[2] Hebrew Univ Jerusalem, Sch Pharm, Fac Med, Jerusalem, Israel

来源：

INTEGRATIVE PHYSIOLOGICAL AND BEHAVIORAL SCIENCE | 2003年 / 38卷 / 02期

关键词：

classical conditioning; nausea; emesis; taste avoidance learning; taste aversion learning; cannabinoids; taste reactivity;

D O I：

10.1007/BF02688831

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Considerable evidence indicates that conditioned gaping in rats reflects nausea in this species that does not vomit. A series of experiments evaluated the potential of psychoactive cannabinoid agonists, Delta-9-THC and HU-210, and non-psychoactive cannabinoids, Cannabidiol (CBD) and its dimethylheptyl homolog (CBD-dmh), to interfere with the establishment and the expression of conditioned gaping in rats. All agents attenuated both the establishment and the expression of conditioned gaping. Furthermore, the CB I antagonist, SR-141716, reversed the suppressive effect of HU-210 on conditioned gaping. Finally, SR-141716 potentiated lithium-induced conditioned gaping, suggesting that the endogenous cannabinoid system plays a role in the control of nausea.

引用

页码：133 / 145

页数：13

共 49 条

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