Tobacco carcinogens, their biomarkers and tobacco-induced cancer

被引：1071

作者：

Hecht, SS ^{[1
]}

机构：

[1] Univ Minnesota, Ctr Canc, Minneapolis, MN 55455 USA

来源：

NATURE REVIEWS CANCER | 2003年 / 3卷 / 10期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrc1190

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The devastating link between tobacco products and human cancers results from a powerful alliance of two factors - nicotine and carcinogens. Without either one of these, tobacco would be just another commodity, instead of being the single greatest cause of death due to preventable cancer. Nicotine is addictive and toxic, but it is not carcinogenic. This addiction, however, causes people to use tobacco products continually, and these products contain many carcinogens. What are the mechanisms by which this deadly combination leads to 30% of cancer-related deaths in developed countries, and how can carcinogen biomarkers help to reveal these mechanisms?

引用

页码：733 / 744

页数：12

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