Convulsant activity and neurochemical alterations induced by a fraction obtained from fruit Averrhoa carambola (Oxalidaceae: Geraniales)

被引：45

作者：

Carolino, ROG

Beleboni, RO

Pizzo, AB

Del Vecchio, F

Garcia-Cairasco, N

Moyses-Neto, M

dos Santos, WF

Coutinho-Netto, J

机构：

[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Fisiol, BR-14049900 Ribeirao Preto, Brazil

[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Bioquim & Imunol, BR-14049900 Ribeirao Preto, Brazil

[3] Univ Sao Paulo, Dept Biol, Fac Filosofia, Ciencias & Letras Ribeirao Preto, BR-14049 Ribeirao Preto, Brazil

[4] Univ Sao Paulo, Fac Med Ribeirao Preto, Hosp Clin, Dept Med Interna,Div Nefrol, Ribeirao Preto, Brazil

来源：

NEUROCHEMISTRY INTERNATIONAL | 2005年 / 46卷 / 07期

基金：

巴西圣保罗研究基金会;

关键词：

Averrhoa carambola; convulsant; video-electroencephalogram; GABA/glutamate uptake; release and binding;

D O I：

10.1016/j.neuint.2005.02.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We obtained a neurotoxic fraction (AcTx) from star fruit (Averrhoa carambola) and studied its effects on GABAergic and glutamatergic transmission systems. AcTx had no effect on GABA/glutamate uptake or release, or on glutamate binding. However, it specifically inhibited GABA binding in a concentration-dependent manner UC50 = 0-89 mu M). Video-electroencephalogram recordings demonstrated that following cortical administration of AcTx, animals showed behavioral changes, including tonic-clonic seizures, evolving into status epilepticus, accompanied by cortical epileptiform. activity. Chemical characterization of AcTx showed that this compound is a nonproteic molecule with a molecular weight less than 500, differing from oxalic acid. This neurotoxic fraction of star fruit may be considered a new tool for neurochemical and neuroethological research. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：523 / 531

页数：9

共 37 条

[1] Investigation of the modulation of glutamate release by sodium channels using neurotoxins [J].