A Ser315Thr substitution in KatG is predominant in genetically heterogeneous multidrug-resistant Mycobacterium tuberculosis isolates originating from the St. Petersburg area in Russia

被引：138

作者：

Marttila, HJ

Soini, H

Eerola, E

Vyshnevskaya, E

Vyshnevskiy, BI

Otten, TF

Vasilyef, AV

Viljanen, MK

机构：

[1] Natl Publ Hlth Inst, Mycobacterial Reference Lab, Dept Turku, Turku 20520, Finland

[2] Turku Univ, Dept Med Microbiol, FIN-20520 Turku, Finland

[3] Res Inst Phthisiopulmonol, St Petersburg, Russia

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1998年 / 42卷 / 09期

关键词：

D O I：

10.1128/AAC.42.9.2443

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Parts of katG and rpoB from 27 Russian Mycobacterium tuberculosis isolates were sequenced to detect mutations causing resistance to isoniazid (INH) and rifampin (RMP), respectively. All 24 INH-resistant isolates had a mutated katG, and 22 of them (91.7%) carried a mutation coding for a Ser315Thr shift. An rpoB mutation aas noted for each of the 21 RMP-resistant isolates, with Ser531Leu being the most prevalent change encoded. Only two isolates had identical IS6110 fingerprints.

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页码：2443 / 2445

页数：3

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