Phosphorus magnetic resonance spectroscopy in schizophrenia: Correlation between membrane phospholipid metabolism in the temporal lobe and positive symptoms

被引：43

作者：

Fukuzako, H ^{[1
]}

Fukuzako, T ^{[1
]}

Takeuchi, K ^{[1
]}

Ohbo, Y ^{[1
]}

Ueyama, K ^{[1
]}

Takigawa, M ^{[1
]}

Fujimoto, T ^{[1
]}

机构：

[1] S JAPAN HLTH SCI CTR,MIYAKONOJO,JAPAN

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1996年 / 20卷 / 04期

关键词：

phosphorus MRS; positive symptoms; schizophrenia; temporal lobe;

D O I：

10.1016/0278-5846(96)00036-X

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1. To determine any correlations between phosphorus metabolites in the temporal lobes and clinical symptoms in schizophrenic patients, the authors performed (31)phosphorus magnetic resonance spectroscopy in 31 medicated patients and age- and sex- matched normal subjects. 2. Schizophrenic patients demonstrated an increased level of phosphodiesters (PDE) in the temporal lobes bilaterally and a decreased level of beta-adenosine triphosphate (beta-ATP) in the left temporal lobe. 3. A significant positive correlation was observed between the level of PDE in the left temporal lobe and the score of positive symptoms on the Brief Psychiatric Rating Scale. 4. These results suggest that altered membrane phospholipid metabolism in the left temporal lobe is associated with neuroleptic-resistant positive symptoms in schizoprenic patients.

引用

页码：629 / 640

页数：12

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