Pinnatoxins B and C, the most toxic components in the pinnatoxin series from the Okinawan bivalve Pinna muricata

被引：115

作者：

Takada, N

Umemura, N

Suenaga, K

Chou, T

Nagatsu, A

Haino, T

Yamada, K

Uemura, D ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Sci, Dept Chem, Chikusa Ku, Nagoya, Aichi 4648602, Japan

[2] Nagoya Univ, Res Ctr Mat Sci, Chikusa Ku, Nagoya, Aichi 4648602, Japan

[3] Sagami Chem Res Ctr, Sagamihara, Kanagawa 2290012, Japan

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 20期

关键词：

D O I：

10.1016/S0040-4039(01)00480-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pinnatoxins B and C, the most toxic components in the pinnatoxin series, were successfully purified from the Okinawan bivalve Pinna muricata. Their gross structures were determined based on NMR and MS/MS spectral analyses. Their stereostructures were mainly determined by transformation reactions. Pinnatoxins B and C, C-34 epimers of each other, have an amphoteric macrocycle composed of 6,7-spiro, 5,6-bicyclo and 6,5,6-trispiro ketal rings, the same as in pinnatoxins A and D. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：3491 / 3494

页数：4

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