A preliminary study of β-cyclodextrin/metoprolol tartrate inclusion complex for potential enantiomeric separation

被引：6

作者：

Radulovic, DM

Karljikovic-Rajic, KD

Lucic, BM

Vujic, ZB

机构：

[1] Univ Belgrade, Fac Pharm, Inst Analyt Chem, YU-11221 Belgrade, Yugoslavia

[2] Univ Belgrade, Fac Pharm, Inst Pharmaceut Chem & Drug Anal, YU-11221 Belgrade, Yugoslavia

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2001年 / 24卷 / 5-6期

关键词：

metoprolol tartrate; beta-cyclodextrin; inclusion complex; UV-spectrophotometry; enantiomeric separation;

D O I：

10.1016/S0731-7085(00)00555-0

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The inclusion complex formation between Metoprolol tartarata (MeT) and beta -cyclodextrin (beta -CD) has been investigated using hyperchromic shift at lambda (max) 274.4 nm of MeT. Different parameters such as stirring time, solvent composition (aqueous and aqueous/methanol solutions with methanol content up to 50%), pH values 4.0 and 8.0 were established for optimal inclusion complex formation and confirmed two stoichiometric compositions 1:1 and 1:2. Preliminary data. on usage of MeT/beta -CD complex in reversed-phase HPLC indicate the potential application of this complex as a kind of pre-column derivatization for enantiomeric separation of beta (1)-blockers. (C) 2001 Published by Elsevier Science B.V.

引用

页码：871 / 876

页数：6

共 18 条

[1] HPLC separation of nadolol and enantiomers on chiralcel OD column [J].