Epstein-Barr virus immediate-early proteins BZLF1 and BRLF1 I alter mitochondrial morphology during lytic replication

被引：16

作者：

LaJeunesse, DR ^{[1
]}

Brooks, K ^{[1
]}

Adamson, AL ^{[1
]}

机构：

[1] Univ N Carolina, Dept Biol, Greensboro, NC 27402 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 333卷 / 02期

关键词：

mitochondria; EBV; BZLF1; BRLF1; JC-1;

D O I：

10.1016/j.bbrc.2005.05.120

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Epstein-Barr virus (EBV) is a human DNA virus that is responsible for the syndrome infectious mononucleosis, and is associated with several forms of cancer. During both lytic and latent viral infection, viral proteins manipulate the host's cellular components to aid in viral replication and maintenance. Here, it is demonstrated that induction of EBV lytic replication results in a dramatic reorganization of mitochondria accompanied by a significant alteration of mitochondrial membrane potential and a rapid and transient increase in the microtubular cytoskeleton. Moreover, we show that expression of the EBV immediate-early genes BZLF1 and BRLF1 contributes to the mitochondrial alteration but not the increase in the microtubule cytoskeleton, suggesting that the mechanism for the observed cytoplasmic restructuring involves a number of coordinated viral and host proteins. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：438 / 442

页数：5

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