Influence of the Glu298Asp polymorphism of NOS3 on age at onset and homocysteine levels in AD patients

被引：30

作者：

Guidi, I

Galimberti, D

Venturelli, E

Lovati, C

Del Bo, R

Fenoglio, C

Gatti, A

Dominici, R

Galbiati, S

Virgilio, R

Pomati, S

Comi, GP

Mariani, C

Forloni, G

Bresolin, N

Scarpini, E

机构：

[1] Univ Milan, Dept Neurol Sci, Dino Ferrari Ctr, IRCCS,Osped Maggiore Policlin, I-20122 Milan, Italy

[2] Univ Milan, Osped L Sacco, Dept Neurol, Milan, Italy

[3] Ist Ric Farmacol Mario Negri, Dept Neurosci, I-20157 Milan, Italy

来源：

NEUROBIOLOGY OF AGING | 2005年 / 26卷 / 06期

关键词：

Alzheimer's disease; polymorphism; endothelial nitric oxide synthase (NOS3); total plasma homocysteine (tHcy); risk factor;

D O I：

10.1016/j.neurobiolaging.2004.07.003

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The distribution of the Glu298Asp polymorphism in NOS3 gene was determined in 405 Italian patients with "probable" Alzheimer's disease (AD) compared with 253 age-matched controls. Total plasma homocysteine (tHcy) levels were evaluated in 97 patients and 23 controls, and were correlated with the Glu298Asp genotype. A significantly increased frequency of the Glu/Glu genotype in late onset AD (LOAD) patients was found. tHcy levels were significantly increased in patients compared with controls and, notably, higher in LOAD than in early onset AD (EOAD). Stratifying by the Glu298Asp genotype, a trend toward an increase of tHcy was present in Glu/Glu homozygous. This wild type genotype seems to be associated with LOAD. tHcy levels are significantly increased in AD compared with controls and, moreover, higher in LOAD than in EOAD, possibly in correlation with the microvascular disease occurring with aging. Besides, a contribution of the Glu/Glu genotype in increasing tHcy levels has been observed. (c) 2004 Elsevier Inc. All rights reserved.

引用

页码：789 / 794

页数：6

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