Therapeutic applications of polymeric artificial cells

被引：243

作者：

Chang, TMS

机构：

[1] McGill Univ, Dept Physiol, Artificial Cells & Organs Res Ctr, Fac Med, Montreal, PQ H3G 1H6, Canada

[2] McGill Univ, Dept Med & Biomed Engn, Artificial Cells & Organs Res Ctr, Fac Med, Montreal, PQ H3G 1H6, Canada

来源：

NATURE REVIEWS DRUG DISCOVERY | 2005年 / 4卷 / 03期

基金：

加拿大健康研究院;

关键词：

D O I：

10.1038/nrd1659

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Polymeric artificial cells have the potential to be used for a wide variety of therapeutic applications, such as the encapsulation of transplanted islet cells to treat diabetic patients. Recent advances in biotechnology, molecular biology, nanotechnology and polymer chemistry are now opening up further exciting possibilities in this field. However, it is also recognized that there are several key obstacles to overcome in bringing such approaches into routine clinical use. This review describes the historical development and principles behind polymeric artificial cells, the present state of the art in their therapeutic application, and the promises and challenges for the future.

引用

页码：221 / 235

页数：15

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