Resynchronisation of a diurnal rodent circadian clock accelerated by a melatonin agonist

被引：33

作者：

Van Reeth, B ^{[1
]}

Olivares, E ^{[1
]}

Turek, FV ^{[1
]}

Granjon, L ^{[1
]}

Mocaer, E ^{[1
]}

机构：

[1] Univ Libre Brussels, Hop Erasme, Fac Med, Ctr Etud Rythmes Biol, B-1070 Brussels, Belgium

来源：

NEUROREPORT | 1998年 / 9卷 / 08期

关键词：

Arvicanthis; circadian clock phase shift; diurnal rodent; jet lag; melatonin agonist;

D O I：

10.1097/00001756-199806010-00043

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

USING 'jet lag' paradigms involving phase shifts in the light-dark (LD) cycle, we studied the effects of S-20098 on the circadian clock of a diurnal rodent. Arvicanthis mordax, entrained to a regular LD cycle, were subjected to advance shifts (i.e. 4, 6 or 8 h) in the LD cycle and injected with vehicle or the melatonin agonist S-20098 (20 mg/kg) the day of the shift (and also on subsequent days in the 6 h or 8 h shift paradigms). In each condition, S-20098 accelerated by about 30% resynchronization to the new LD cycle. These data, which are the first to demonstrate the chronobiotic effects of a melatonin agonist in a diurnal rodent, provide new insights for the design of human chronopharmacological protocols. (C) 1998 Rapid Science Ltd.

引用

页码：1901 / 1905

页数：5

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