Anti-viral immunity: Spotting virus-specific T cells

被引：14

作者：

Tough, DF ^{[1
]}

Sprent, J

机构：

[1] Edward Jenner Inst Vaccine Res, Newbury RG2 7NN, Berks, England

[2] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

来源：

CURRENT BIOLOGY | 1998年 / 8卷 / 14期

关键词：

D O I：

10.1016/S0960-9822(98)70317-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Historically, quantitation of virus-specific CD8(+) T cells has been accomplished by limiting dilution analysis of cytotoxic precursor cells. Recent studies have shown that this technique greatly underestimates the actual number of antigen specific cells and have provided new insight into anti-viral immune responses.

引用

页码：R498 / R501

页数：4

共 15 条

[1] Phenotypic analysis of antigen-specific T lymphocytes
Altman, JD
Moss, PAH
Goulder, PJR
Barouch, DH
McHeyzerWilliams, MG
Bell, JI
McMichael, AJ
Davis, MM
[J]. SCIENCE, 1996, 274 (5284) : 94 - 96
[2] LYMPHOCYTIC CHORIOMENINGITIS VIRUS-INFECTION IS ASSOCIATED WITH LONG-STANDING PERTURBATION OF LFA-1 EXPRESSION ON CD8(+) T-CELLS
ANDERSSON, EC
CHRISTENSEN, JP
SCHEYNIUS, A
MARKER, O
THOMSEN, AR
[J]. SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1995, 42 (01) : 110 - 118
[3] Massive expansion of antigen-specific CD8+ T cells during an acute virus infection
Butz, EA
Bevan, MJ
[J]. IMMUNITY, 1998, 8 (02) : 167 - 175
[4] Antigen-specific CD8(+) T cell subset distribution in lymph nodes draining the site of herpes simplex virus infection
Cose, SC
Jones, CM
Wallace, ME
Heath, WR
Carbone, FR
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1997, 27 (09) : 2310 - 2316
[5] Bystander activation of cytotoxic T cells: Studies on the mechanism and evaluation of in vivo significance in a transgenic mouse model
Ehl, S
Hombach, J
Aichele, P
Hengartner, H
Zinkernagel, RM
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 185 (07) : 1241 - 1251
[6] Fazekas de St G S, 1982, J IMMUNOL METHODS, V49, pR11
[7] Gallimore A, 1998, J EXP MED, V187, P1647
[8] EXPRESSION OF CYTOPLASMIC GRANULES WITH T-CELL-ASSOCIATED SERINE PROTEINASE-1 ACTIVITY IN LY-2+ (CD8+) LYMPHOCYTES-T RESPONDING TO LYMPHOCYTIC CHORIOMENINGITIS VIRUS INVIVO
KRAMER, MD
FRUTH, U
SIMON, HG
SIMON, MM
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1989, 19 (01) : 151 - 156
[9] THE IMMUNE-RESPONSE OF THE MOUSE TO LYMPHOCYTIC CHORIOMENINGITIS VIRUS .5. HIGH NUMBERS OF CYTOLYTIC LYMPHOCYTES-T ARE GENERATED IN THE SPLEEN DURING ACUTE INFECTION
MOSKOPHIDIS, D
ASSMANNWISCHER, U
SIMON, MM
LEHMANNGRUBE, F
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1987, 17 (07) : 937 - 942
[10] Counting antigen-specific CD8 T cells: A reevaluation of bystander activation during viral infection
Murali-Krishna, K
Altman, JD
Suresh, M
Sourdive, DJD
Zajac, AJ
Miller, JD
Slansky, J
Ahmed, R
[J]. IMMUNITY, 1998, 8 (02) : 177 - 187

← 1 2 →