Evolution of subspecies of Francisella tularensis

被引:102
作者
Svensson, K
Larsson, P
Johansson, D
Byström, M
Forsman, M
Johansson, A [1 ]
机构
[1] Swedish Def Res Agcy, Dept NBC Anal, SE-90182 Umea, Sweden
[2] Umea Univ, Dept Clin Microbiol Bacteriol, SE-90185 Umea, Sweden
[3] Umea Univ, Dept Clin Microbiol Infest Dis, SE-90185 Umea, Sweden
关键词
D O I
10.1128/JB.187.11.3903-3908.2005
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Analysis of unidirectional genomic deletion events and single nucleotide variations suggested that the four subspecies of Francisella tularensis have evolved by vertical descent. The analysis indicated an evolutionary scenario where the highly virulent F. tularensis subsp. tularensis (type A) appeared before the less virulent F. tularensis subsp. holarctica (type B). Compared to their virulent progenitors, attenuated strains of F. tularensis exhibited specific unidirectional gene losses.
引用
收藏
页码:3903 / 3908
页数:6
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