The catalytic mechanism of cytochrome P450 BM3 involves a 6 angstrom movement of the bound substrate on reduction

被引：126

作者：

Modi, S

Sutcliffe, MJ

Primrose, WU

Lian, LY

Roberts, GCK

机构：

[1] UNIV LEICESTER, DEPT BIOCHEM, LEICESTER LE1 9HN, LEICS, ENGLAND

[2] UNIV LEICESTER, DEPT CHEM, LEICESTER LE1 9HN, LEICS, ENGLAND

[3] UNIV LEICESTER, BIOL NMR CTR, LEICESTER LE1 9HN, LEICS, ENGLAND

[4] UNIV LEICESTER, CTR MECH HUMAN TOX, LEICESTER LE1 9HN, LEICS, ENGLAND

来源：

NATURE STRUCTURAL BIOLOGY | 1996年 / 3卷 / 05期

关键词：

D O I：

10.1038/nsb0596-414

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Paramagnetic relaxation measurements show that reduction of the cytochrome P450 BM3-substrate complex is accompanied by a structural change leading to a 6 Angstrom, movement of the substrate into the correct position and orientation for hydroxylation.

引用

页码：414 / 417

页数：4

共 26 条

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