Update on osteoporosis in men

被引：58

作者：

Adler, Robert A. ^{[1
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机构：

[1] McGuire Vet Affairs Med Ctr, Endocrinol & Metab Sect, Endocrinol & Metab, 1201 Broad Rock Blvd, Richmond, VA 23249 USA

[2] McGuire Vet Affairs Med Ctr, Endocrinol & Metab Sect, Internal Med, 1201 Broad Rock Blvd, Richmond, VA 23249 USA

[3] Virginia Commonwealth Univ, Sch Med, Div Endocrine, Endocrinol & Metab, Med Coll Virginia Campus, Richmond, VA 23298 USA

[4] Virginia Commonwealth Univ, Sch Med, Div Endocrine, Internal Med, Med Coll Virginia Campus, Richmond, VA 23298 USA

[5] McGuire Vet Affairs Med Ctr, Endocrinol & Metab Sect, 1201 Broad Rock Blvd, Richmond, VA 23249 USA

来源：

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2018年 / 32卷 / 05期

关键词：

osteoporosis; men; fracture; bisphosphonates; denosumab; teriparatide; BONE-MINERAL DENSITY; GLUCOCORTICOID-INDUCED OSTEOPOROSIS; HIP FRACTURE; OLDER MEN; VERTEBRAL FRACTURES; ANDROGEN-DEPRIVATION; ANTIRESORPTIVE THERAPY; SECONDARY OSTEOPOROSIS; POSTMENOPAUSAL WOMEN; TESTOSTERONE LEVELS;

D O I：

10.1016/j.beem.2018.05.007

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Osteoporosis in men remains under-diagnosed and under appreciated. After a low trauma fracture, a man is less likely to have evaluation and treatment. The lifetime risk for osteoporotic fracture in older men may range from 13 to 25%, and as men live longer, there will be more fractures. Newer strategies for determining which men should have bone density testing are emerging. Information from observational studies are providing insights that allow targeted testing and treatment of those men at the highest risk for fracture. Treatment with most of the same medications used in women is efficacious and generally safe. Nonetheless, the fear of side effects of treatments for an asymptomatic disorder (before a fracture) and other barriers have made management challenging in men at risk for fracture. This review provides updates on epidemiology, pathophysiology, evaluation and treatment of male osteoporosis. Published by Elsevier Ltd.

引用

页码：759 / 772

页数：14

共 92 条

[1]

Risk of hip, subtrochanteric, and femoral shaft fractures among mid and long term users of alendronate: nationwide cohort and nested case-control study [J].