Epidemiology of systemic lupus erythematosus in a northern Spanish population:: gender and age influence on immunological features

被引:116
作者
López, P
Mozo, L
Gutiérrez, C
Suárez, A
机构
[1] Univ Oviedo, Fac Med, Area Immunol, Dept Funct Biol, E-33006 Oviedo, Spain
[2] Univ Oviedo, Hosp Cent Asturias, Dept Immunol, E-33080 Oviedo, Spain
关键词
age; autoantibodies; epidemiology; lupus; sex;
D O I
10.1191/0961203303lu469xx
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The present work was planned to research epidemiological and immunological features of systemic lupus erythematosus (SLE) in a Caucasian population from the north of Spain (Asturias). There is only one specialized immunology laboratory in this region where samples from all patients with a plausible or a firm diagnosis of SLE are referred for immunological analysis. Since 1992 we have reviewed registered data from samples submitted to the immunology laboratory with a firm, definitive diagnosis of SLE, based on the fulfillment of the American College of Rheumatology (ACR) criteria. We have constructed a database, which included 367 SLE patients. The point prevalence was 34.12/ 100 000 (95% Cl: 30.63 -37.61 / 100 000), whereas the incidence rate calculated during the last five years was 2.15/100 000/year (95% Cl: 1.76-2.54/100 000/year). The female/male ratio varied according to the age at diagnosis, being maximum (50: 1) between 22 and 28 years. The median age at diagnostis was significantly lower in females than in males. Immunological features also yielded sex and age peculiarities. The percentage of patients with anti-SSa antibodies yielded significant differences between males (18.6%) and females (34.6%). Anti-RNP and anti-Sm antibodies were more frequently present in childhood-onset patients, the difference with the oldest-onset group being statistically significant. Other analyses did not show significant differences, although, as a whole, we observed a trend towards a higher presence of autoantibodies related to an early disease onset.
引用
收藏
页码:860 / 865
页数:6
相关论文
共 36 条
[1]   CLINICAL-FEATURES OF SYSTEMIC LUPUS-ERYTHEMATOSUS - DIFFERENCES RELATED TO RACE AND AGE OF ONSET [J].
BALLOU, SP ;
KHAN, MA ;
KUSHNER, I .
ARTHRITIS AND RHEUMATISM, 1982, 25 (01) :55-60
[2]   Survival analysis of 306 European Spanish patients with systemic lupus erythematosus [J].
Blanco, FJ ;
Gomez-Reino, JJ ;
de la Mata, J ;
Corrales, A ;
Rodriguez-Valverde, V ;
Rosas, JC ;
de la Camara, AG ;
Pascual, E .
LUPUS, 1998, 7 (03) :159-163
[3]   Risk factors for damage in childhood-onset systemic lupus erythematosus - Cumulative disease activity and medication use predict disease damage [J].
Brunner, HI ;
Silverman, ED ;
To, T ;
Bombardier, C ;
Feldman, BM .
ARTHRITIS AND RHEUMATISM, 2002, 46 (02) :436-444
[4]   SYSTEMIC LUPUS-ERYTHEMATOSUS - CLINICAL AND IMMUNOLOGICAL PATTERNS OF DISEASE EXPRESSION IN A COHORT OF 1,000 PATIENTS [J].
CERVERA, R ;
KHAMASHTA, MA ;
FONT, J ;
SEBASTIANI, GD ;
GIL, A ;
LAVILLA, P ;
DOMENECH, I ;
AYDINTUG, AO ;
JEDRYKAGORAL, A ;
DERAMON, E ;
GALEAZZI, M ;
HAGA, HJ ;
MATHIEU, A ;
HOUSSIAU, F ;
INGELMO, M ;
HUGHES, GRV ;
CERVERA, R ;
SEBASTIANI, GD ;
FONT, J ;
KHAMASHTA, MA ;
HUGHES, GRV ;
FONT, J ;
CERVERA, R ;
LOPEZSOTO, A ;
VIVANCOS, J ;
INGELMO, M ;
URBANOMARQUEZ, A ;
KHAMASHTA, MA ;
VIANNA, J ;
HUGHES, GRV ;
GIL, A ;
LAVILLA, P ;
PINTADO, V ;
LOPEZDUPLA, M ;
VAZQUEZ, JJ ;
SEBASTIANI, GD ;
DERAMON, E ;
CAMPS, M ;
FRUTOS, MA ;
PERELLO, I ;
SANTOS, PG ;
ABARCA, M ;
NEBRO, AF ;
DOMENECH, I ;
TOKGOZ, G ;
AYDINTUG, AO ;
JEDRYKAGORAL, A ;
MALDYKOWA, H ;
CHWALINSKASADOWSKA, H ;
GALEAZZI, M .
MEDICINE, 1993, 72 (02) :113-124
[5]   Differences by race, sex and age in the clinical and immunologic features of recently diagnosed systemic lupus erythematosus patients in the southeastern United States [J].
Cooper, GS ;
Parks, CG ;
Treadwell, EL ;
St Clair, EW ;
Gilkeson, GS ;
Cohen, PL ;
Roubey, RAS ;
Dooley, MA .
LUPUS, 2002, 11 (03) :161-167
[6]   Systemic lupus erythematosus in Martinique, French West Indies:: an epidemiology-based study. [J].
Deligny, C ;
Thomas, L ;
Dubreuil, F ;
Théodose, C ;
Garsaud, AM ;
Numéric, P ;
Ranlin, A ;
Jean-Baptiste, G ;
Arfi, S .
REVUE DE MEDECINE INTERNE, 2002, 23 (01) :21-29
[7]   Systemic lupus erythematosus (SLE) in childhood:: analysis of clinical and immunological findings in 34 patients and comparison with SLE characteristics in adults [J].
Font, J ;
Cervera, R ;
Espinosa, G ;
Pallarés, L ;
Ramos-Casals, M ;
Jiménez, S ;
García-Carrasco, M ;
Seisdedos, L ;
Ingelmo, M .
ANNALS OF THE RHEUMATIC DISEASES, 1998, 57 (08) :456-459
[8]   Clinical and serological characteristics in 128 patients with systemic lupus erythematosus [J].
Ghedira, I ;
Sakly, W ;
Jeddi, M .
PATHOLOGIE BIOLOGIE, 2002, 50 (01) :18-24
[9]   Consistent production of a higher TH1:TH2 cytokine ratio by stimulated T cells in men compared with women [J].
Girón-González, JA ;
Moral, FJ ;
Elvira, J ;
García-Gil, D ;
Guerrero, F ;
Gavilán, I ;
Escobar, L .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2000, 143 (01) :31-36
[10]   The prevalence of systemic lupus erythematosus in Northern Ireland [J].
Gourley, IS ;
Patterson, CC ;
Bell, AL .
LUPUS, 1997, 6 (04) :399-403