Escaping Anoikis through ROS: ANGPTL4 Controls Integrin Signaling through Nox1

被引：23

作者：

Terada, Lance S. ^{[1
]}

Nwariaku, Fiemu E. ^{[2
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Dallas, TX 75390 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Surg, Dallas, TX 75390 USA

来源：

CANCER CELL | 2011年 / 19卷 / 03期

关键词：

CELL-MIGRATION; TRANSFORMATION;

D O I：

10.1016/j.ccr.2011.02.019

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Reactive oxygen species (ROS) mediate various cell fate decisions in normal and transformed cells. In this issue of Cancer Cell, Zhu et al. demonstrate the ability of ANGPTL4 to engage integrin-dependent survival signals by activation of the NADPH oxidase Nox1, thus mimicking anchorage conditions and bypassing anoikis by controlling ROS.

引用

页码：297 / 299

页数：3

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