Non-Hodgkin's lymphomas and myeloid disorders: deletions associated with t(2;5) and t(3;5) detected by FISH

被引：9

作者：

Dragon-Durey, MA

Goguel, AF

Leonard, C

Berger, R

Bressac-de-Paillerets, B

Fauvet, D

Bernheim, A

机构：

[1] Inst Gustave Roussy, Lab Cytogenet & Genet Oncol, URA 1967 CNRS, F-94805 Villejuif, France

[2] Inst Gustave Roussy, Unite Marqueurs Genet Canc, F-94805 Villejuif, France

[3] CHU Kremlin Bicetre, Le Kremlin Bicetre, France

[4] U 301 INSERM, Paris, France

[5] SD 401 301 CNRS IGM, Paris, France

来源：

LEUKEMIA | 1998年 / 12卷 / 07期

关键词：

anaplastic large cell lymphoma; myeloid disorders; t(2; 5); t(3; NPM; FISH;

D O I：

10.1038/sj.leu.2401047

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The nucleophosmin (NPM) gene is involved in two recurrent translocations in hematological malignancies: t(2;5) (p23;q35) in anaplastic large cell lymphoma (ALCL) and t(3;5)(q25.1;q34-35) in myelodysplasia and acute non-lymphocytic leukemia (ANLL). Using eight YACs encompassing the 5q34-q35 region, we could easily detect these two translocations. In both types of translocation, probable unexpected deletions were also discovered downstream of the breakpoint at 5q35.

引用

页码：1159 / 1162

页数：4

共 18 条

[1] MOLECULAR-BASIS OF 11Q23 REARRANGEMENTS IN HEMATOPOIETIC MALIGNANT PROLIFERATIONS [J].