Metformin for aging and cancer prevention

被引：125

作者：

Anisimov, Vladimir N. ^{[1
]}

机构：

[1] NN Petrov Res Inst Oncol, Dept Carcinogenesis & Oncogerontol, St Petersburg 197758, Russia

来源：

AGING-US | 2010年 / 2卷 / 11期

基金：

俄罗斯基础研究基金会;

关键词：

metformin; biguanides; life span; aging; cancer prevention; EXTENDS LIFE-SPAN; CALORIC RESTRICTION MIMETICS; ANTIDIABETIC DRUG METFORMIN; ACTIVATED PROTEIN-KINASE; BREAST-CANCER; DIETARY RESTRICTION; INSULIN-RESISTANCE; OXIDATIVE STRESS; C-ELEGANS; METABOLIC IMMUNODEPRESSION;

D O I：

10.18632/aging.100230

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors in aging. Insulin/insulin-like growth factor 1 (IGF-1) signaling molecules that have been linked to longevity include daf-2 and InR and their homologues in mammals, and inactivation of the corresponding genes increases life span in nematodes, fruit flies and mice. It is possible that the life-prolonging effect of caloric restriction is due to decreasing IGF-1 levels. Evidence has emerged that antidiabetic drugs are promising candidates for both life span extension and prevention of cancer. Thus, antidiabetic drugs postpone spontaneous carcinogenesis in mice and rats, as well as chemical and radiation carcinogenesis in mice, rats and hamsters. Furthermore metformin seems to decrease cancer risk in diabetic patients.

引用

页码：760 / 774

页数：15

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