High levels of urinary midkine in various cancer patients

被引：53

作者：

Ikematsu, S

Okamoto, K

Yoshida, Y

Oda, M

Sugano-Nagano, H

Ashida, K

Kumai, H

Kadomatsu, K

Muramatsu, H

Muramatsu, T

Sakuma, S

机构：

[1] Nagoya Univ, Grad Sch Med, Dept Biochem, Showa Ku, Nagoya, Aichi 4668550, Japan

[2] Meiji Dairies Corp, Kanagawa 2500862, Japan

[3] Univ Occupat & Environm Hlth, Dept Surg, Yahatanishi Ku, Kitakyushu, Fukuoka 8070804, Japan

[4] Kagoshima Univ, Fac Med, Sch Hlth Sci, Kagoshima 8908506, Japan

[5] Cell Signals Inc, Tsurumi Ku, Yokohama, Kanagawa 2300046, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2003年 / 306卷 / 02期

关键词：

midkine; tumor marker; enzyme-linked immunoassay; urine;

D O I：

10.1016/S0006-291X(03)00984-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Midkine (MK) is a heparin-binding growth factor, which promotes growth, migration, and survival of various cells, and MK expression is increased in many human carcinomas. We determined the urinary MK level by enzyme-linked immunoassay. Taking 311 pg/mg creatinine as a cut-off level, 70% of patients with various carcinomas (n = 142) gave positive values, while only 5.5% of healthy volunteers (n = 330) did. In case of gastric carcinoma, 17 out of 21 patients with stage I tumor were positive. Urinary MK levels are expected to become a convenient marker as an aid in detection of tumors. (C) 2003 Elsevier Science (USA). All rights reserved.

引用

页码：329 / 332

页数：4

共 32 条

[1]

INCREASED MIDKINE GENE-EXPRESSION IN HUMAN GASTROINTESTINAL CANCERS [J].