Short-term administration of tall oil phytosterols improves plasma lipid profiles in subjects with different cholesterol levels

被引:50
作者
Jones, PJH [1 ]
Howell, T [1 ]
MacDougall, DE [1 ]
Feng, JY [1 ]
Parsons, W [1 ]
机构
[1] McGill Univ, Sch Dietet & Human Nutr, Ste Anne De Bellevue, PQ H9X 3V9, Canada
来源
METABOLISM-CLINICAL AND EXPERIMENTAL | 1998年 / 47卷 / 06期
关键词
D O I
10.1016/S0026-0495(98)90041-5
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
To assess the short-term cholesterol-lowering potential of sitostanol-containing tall oil plant sterols, 22 subjects consumed fixed-food diets over two 10-day periods with or without 21.2 mg/kg body weight/d tall oil phytosterols (sitosterol 62%, sitostanol 21%, campesterol 16%, and campestanol 1%) in a randomized crossover study design. On day 10 of each diet, plasma lipoprotein cholesterol levels, plasma phytosterol concentrations, and cholesterol biosynthesis rates were determined. Total cholesterol (TC) and low-density lipoprotein (LDL) cholesterol levels were lower (P < .01) after administration of tall oil phytosterol (4.7 +/- 0.3 and 3.0 +/- 0.3 mmol/L, respectively) versus placebo (5.0 +/- 0.3 and 3.2 +/- 0.3 mmol/L, respectively). Tall oil treatment had no effect on the plasma high-density lipoprotein (HDL) cholesterol level (1.1 +/- 0.1 mmol/L) versus placebo (1.1 +/- 0.1 mmol/L). Similarly, plasma triglyceride (TG) levels did not differ between tall oil (1.3 +/- 0.2 mmol/L) and placebo (1.4 +/- 0.2 mmol/L) treatments. Plasma campesterol (15.8 +/- 3.7 mmol/mol cholesterol) and sitosterol (6.0 +/- 2.1 mmol/mol cholesterol) levels were not different after tall oil treatment versus placebo treatment (15.4 +/- 2.3 and 6.4 +/- 2.0 mmol/mol cholesterol, respectively). Plasma sitostanol levels were essentially undetectable. No difference was observed in cholesterol biosynthesis between tall oil (0.045 +/- 0.004 pools/d) and placebo (0.034 +/- 0.004 pools/d) treatments; however, the effect of treatments in subjects with different cholesterol levels varied. In subjects with lower cholesterol values, the red blood cell cholesterol fractional synthesis rate (FSR) increased from 0.0291 +/- 0.0054 pools/d after placebo to 0.0509 +/- 0.0049 pools/d (P < .05) after phytosterol treatment. In subjects with higher cholesterol values, the red blood cell cholesterol FSR did not change significantly after treatment. These results demonstrate the short-term efficacy of tall oil plant sterols as cholesterol-lowering agents. Copyright (C) 1998 by W.B. Saunders Company.
引用
收藏
页码:751 / 756
页数:6
相关论文
共 27 条
[1]   TREATMENT OF SEVERE FAMILIAL HYPERCHOLESTEROLEMIA IN CHILDHOOD WITH SITOSTEROL AND SITOSTANOL [J].
BECKER, M ;
STAAB, D ;
VONBERGMANN, K .
JOURNAL OF PEDIATRICS, 1993, 122 (02) :292-296
[2]  
BECKER M, 1992, PEDIATRICS, V89, P138
[3]   LACK OF EFFICACY OF LOW-DOSE SITOSTANOL THERAPY AS AN ADJUNCT TO A CHOLESTEROL-LOWERING DIET IN MEN WITH MODERATE HYPERCHOLESTEROLEMIA [J].
DENKE, MA .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1995, 61 (02) :392-396
[4]   THE EFFECT OF BETA SITOSTEROL ON THE SERUM LIPIDS OF YOUNG MEN WITH ARTERIOSCLEROTIC HEART DISEASE [J].
FARQUHAR, JW ;
SMITH, RE ;
DEMPSEY, ME .
CIRCULATION, 1956, 14 (01) :77-82
[5]  
FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
[6]   SERUM-CHOLESTEROL AND CHOLESTEROL AND LIPOPROTEIN METABOLISM IN HYPERCHOLESTEROLEMIC NIDDM PATIENTS BEFORE AND DURING SITOSTANOL ESTER-MARGARINE TREATMENT [J].
GYLLING, H ;
MIETTINEN, TA .
DIABETOLOGIA, 1994, 37 (08) :773-780
[7]  
GYLLING H, 1995, J LIPID RES, V36, P1807
[8]   COMPARISON OF INTESTINAL-ABSORPTION OF CHOLESTEROL WITH DIFFERENT PLANT STEROLS IN MAN [J].
HEINEMANN, T ;
AXTMANN, G ;
VONBERGMANN, K .
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 1993, 23 (12) :827-831
[9]   MECHANISMS OF ACTION OF PLANT STEROLS ON INHIBITION OF CHOLESTEROL ABSORPTION - COMPARISON OF SITOSTEROL AND SITOSTANOL [J].
HEINEMANN, T ;
KULLAKUBLICK, GA ;
PIETRUCK, B ;
VONBERGMANN, K .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1991, 40 :S59-S63
[10]  
Helrich K., 1990, ASS OFFICIAL ANAL CH