Mass spectrometry of peptides in neuroscience

被引：46

作者：

Nilsson, CL ^{[1
]}

Karlsson, G ^{[1
]}

Bergquist, J ^{[1
]}

Westman, A ^{[1
]}

Ekman, R ^{[1
]}

机构：

[1] Univ Goteborg, Dept Psychiat & Neurochem, Inst Clin Neurosci, Sahlgrenska Univ Hosp Molndal, S-43180 Molndal, Sweden

来源：

PEPTIDES | 1998年 / 19卷 / 04期

关键词：

neuropeptides; electrospray ionization mass spectrometry; matrix-assisted laser desorption/ionization mass spectrometry;

D O I：

10.1016/S0196-9781(97)00471-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review focuses on the contributions of modern mass spectrometry to neuropeptide research. An introduction to newer mass spectrometric techniques is provided. Also, the use of mass spectrometry in combination with high-resolution separation techniques for neuropeptide identification in biological samples is illustrated. The amino acid sequence information that is important for the identification and analysis of known, novel, or chemically modified neuropeptides may be obtained using mass spectrometric techniques. Because mass spectrometry techniques can be used to reflect the dynamic properties associated with neuropeptide processing in biological systems, they may be used in the future to monitor peptide profiles within organisms in response to environmental challenges such as disease and stress. (C) 1998 Elsevier Science Inc.

引用

页码：781 / 789

页数：9

共 65 条

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