A dramatic reversal of facial selectivity in the sharpless asymmetric dihydroxylation of a sterically hindered 3-methylidene-benzofuran

被引：26

作者：

Krysan, DJ

机构：

[1] Hoechst Marion Roussel Res. Inst., Cincinnati, OH 45215

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 09期

关键词：

D O I：

10.1016/0040-4039(96)00057-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A dramatic reversal of pi-facial selectivity in the osmium-catalyzed asymmetric dihydroxylation (AD) of an exocyclic olefin is reported; wherein, switching from a phthalazine-linked ligand to a pyrimidine-linked ligand led to the opposite enantiomer using the same psuedoenantiomer of the cinchona alkaloid.

引用

收藏

页码：1375 / 1376

页数：2

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