Hepatic and renal pathology of intraperitoneally administered microcystin-LR in rainbow trout (Oncorhynchus mykiss)

被引:147
作者
Kotak, BG
Semalulu, S
Fritz, DL
Prepas, EE
Hrudey, SE
Coppock, RW
机构
[1] ALBERTA ENVIRONM CTR,ENVIRONM TOXICOL PROGRAM,VEGREVILLE,AB T0B 4L0,CANADA
[2] USA,MED RES INST INFECT DIS,DIV PATHOL,FREDERICK,MD 21702
[3] UNIV ALBERTA,FAC MED,ENVIRONM HLTH PROGRAM,EDMONTON,AB T6G 2G3,CANADA
基金
加拿大自然科学与工程研究理事会;
关键词
D O I
10.1016/0041-0101(96)00009-8
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
B. G. Kotak, S. Semalulu, D. L. Fritz, E. E. Prepas, S. E. Hrudey and R. W. Coppock. Hepatic and renal pathology of intraperitoneally administered microcystin-LR in rainbow trout (Oncorhynchus mykiss). Toxicon 34, 517-525, 1996.-In 26 hr laboratory trials a dose of 1000 mu g/kg microcystin-LR (MC-LR) caused 100% mortality in rainbow trout, while no mortality was observed at doses of 400 mu g/kg or less. The liver to body mass ratio increased in fish exposed to the toxin which was likely due to water retention in the liver. In contrast to mammalian studies, hemorrhage of the liver was rare in fish. Exposure to MC-LR caused widespread hepatocellular swelling and lysis of hepatocyte plasma membranes, resulting in liquifactive necrosis (organelles floating in a milieux of cellular debris). Kidney lesions in the fish consisted of coagulative tubular necrosis with a dilation of Bowman's space. Lesions observed in the liver and kidney of fish exposed to MC-LR were considerably different than those previously reported for mammals. Copyright (C) 1996 Elsevier Science Ltd.
引用
收藏
页码:517 / 525
页数:9
相关论文
共 28 条
  • [1] PATHO-PHYSIOLOGY OF CYANOGINOSIN-LR - INVIVO AND INVITRO STUDIES
    ADAMS, WH
    STONE, JP
    SYLVESTER, B
    STONER, RD
    SLATKIN, DN
    TEMPEL, NR
    SIEGELMAN, HW
    [J]. TOXICOLOGY AND APPLIED PHARMACOLOGY, 1988, 96 (02) : 248 - 257
  • [2] CHEMICAL AND BIOLOGICAL EVIDENCE LINKS MICROCYSTINS TO SALMON NETPEN LIVER-DISEASE
    ANDERSEN, RJ
    LUU, HA
    CHEN, DZX
    HOLMES, CFB
    KENT, ML
    LEBLANC, M
    TAYLOR, FJRM
    WILLIAMS, DE
    [J]. TOXICON, 1993, 31 (10) : 1315 - 1323
  • [3] BOZZOLLA JJ, 1992, ELECTR MICROSCOPY PR
  • [4] Carmichael W.W., 1988, Handbook of Natural Toxins, V3, P121
  • [5] Carmichael W.W., 1978, MITT INT VER LIMNOL, V21, P1953, DOI 10.1080/05384680.1978.11903972
  • [6] CYANOBACTERIA SECONDARY METABOLITES - THE CYANOTOXINS
    CARMICHAEL, WW
    [J]. JOURNAL OF APPLIED BACTERIOLOGY, 1992, 72 (06): : 445 - 459
  • [7] *CCAC, 1984, GUID CAR US EXPT AN
  • [8] GALEY FD, 1987, AM J VET RES, V48, P1415
  • [9] Acute toxicity, behavioral changes, and histopathological effects of deltamethrin on tissues (gills, liver, brain, spleen, kidney, muscle, skin) of Nile tilapia (Oreochromis niloticus L.) fingerlings
    Yildirim, M. Zilynet
    Benli, A. Çaglan Karasu
    Selvi, Mahmut
    Özkul, Ayhan
    Erkoç, Figen
    Koçak, Oner
    [J]. ENVIRONMENTAL TOXICOLOGY, 2006, 21 (06) : 614 - 620
  • [10] MICROCYSTIN-LR-INDUCED ULTRASTRUCTURAL-CHANGES IN RATS
    HOOSER, SB
    BEASLEY, VR
    BASGALL, EJ
    CARMICHAEL, WW
    HASCHEK, WM
    [J]. VETERINARY PATHOLOGY, 1990, 27 (01) : 9 - 15