Low cardiorespiratory fitness is a strong predictor for clustering of cardiovascular disease risk factors in children independent of country, age and sex

被引:224
作者
Anderssen, Sigmund A.
Cooper, Ashley R.
Riddoch, Chris
Sardinha, Luis B.
Harro, Maarike
Brage, Soren
Andersen, Lars B.
机构
[1] Norwegian Sch Sports Sci, Dept Sports Med, N-0806 Oslo, Norway
[2] Univ Bristol, Bristol BS8 1TH, Avon, England
[3] Middlesex Univ, London Sport Inst, London N17 8HR, England
[4] Univ Tecn Lisboa, Fac Human Movement, Lisbon, Portugal
[5] Natl Inst Hlth Dev, Tallinn, Estonia
[6] MRC Epidemiol Unit, Cambridge, England
来源
EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION | 2007年 / 14卷 / 04期
基金
英国医学研究理事会;
关键词
cardiovascular risk fitness; insulin; paediatrics;
D O I
10.1097/HJR.0b013e328011efc1
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background and design Few studies have investigated the association between maximal cardiorespiratory capacity (fitness) and the clustered cardiovascular disease (CVD) risk in children and youth from culturally diverse countries. This cross-sectional study examined the association between fitness and clustered CVD risk in children and adolescents from three European countries. Methods Participants were 2845 randomly selected school children aged 9 or 15 years from Portugal (n=944), Denmark (n = 849) and Estonia (n = 1052). Cardiorespiratory fitness was determined during a maximal test on a cycle ergometer. CVD risk factors selected to assess the degree of clustering were the total cholesterol/high-density lipoprotein cholesterol ratio, plasma triglycerides, insulin resistance (homeostasis model assessment), sum of four skinfolds, and systolic blood pressure. Results There was a strong association between cardiorespiratory fitness and the clustering of CVD risk factors. The odds ratios for clustering in each quartile of fitness, using the quartile with the highest fitness as reference, were 13.0 [95% confidence interval (CI) 8.8-19.1]; 4.8 (95% Cl 3.2-7.1) and 2.5 (95% Cl 1.6-3.8), respectively, after adjusting for country, age, sex, socio-economic status, pubertal stage, family history of CVD and diabetes. In stratified analyses by age group, sex and country, similar strong patterns were observed. Conclusion Low cardiorespiratory fitness is strongly associated with the clustering of CVD risk factors in children independent of country, age and sex.
引用
收藏
页码:526 / 531
页数:6
相关论文
共 29 条
[1]  
Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO
[2]  
2-S
[3]   Biological cardiovascular risk factors cluster in Danish children and adolescents: the European Youth Heart Study [J].
Andersen, LB ;
Wedderkopp, N ;
Hansen, HS ;
Cooper, AR ;
Froberg, K .
PREVENTIVE MEDICINE, 2003, 37 (04) :363-367
[4]   MAXIMAL OXYGEN-UPTAKE IN DANISH ADOLESCENTS 16-19 YEARS OF AGE [J].
ANDERSEN, LB ;
HENCKEL, P ;
SALTIN, B .
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, 1987, 56 (01) :74-82
[5]  
[Anonymous], 2005, J Phys Act Health, V2, P115, DOI [10.1123/jpah.2.1.115, DOI 10.1123/JPAH.2.1.115]
[6]  
BAO WH, 1994, ARCH INTERN MED, V154, P1842
[7]   Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults [J].
Berenson, GS ;
Srinivasan, SR ;
Bao, WH ;
Newman, WP ;
Tracy, RE ;
Wattigney, WA .
NEW ENGLAND JOURNAL OF MEDICINE, 1998, 338 (23) :1650-1656
[8]  
Boreham C, 2002, INT J SPORTS MED, V23, pS22
[9]  
Boreham C, 2001, MED SCI SPORT EXER, V33, P270
[10]   Features of the metabolic syndrome are associated with objectively measured physical activity and fitness in Danish children - the European Youth Heart Study (EYHS) [J].
Brage, S ;
Wedderkopp, N ;
Ekelund, U ;
Franks, PW ;
Wareham, NJ ;
Andersen, LB ;
Froberg, K .
DIABETES CARE, 2004, 27 (09) :2141-2148