Lembehyne a, a novel neuritogenic polyacetylene, from a marine sponge of Haliclona sp.

被引：41

作者：

Aoki, S

Matsui, K

Tanaka, K

Satari, R

Kobayashi, M

机构：

[1] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan

[2] LIPI, Res & Dev Ctr Oceanol, Jakarta 11048, Indonesia

来源：

TETRAHEDRON | 2000年 / 56卷 / 51期

关键词：

neuritogenic; polyacetylene; lembehyne A;

D O I：

10.1016/S0040-4020(00)00973-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Lembehyne A (1), a novel long chain polyacetylene, which induces neurite outgrowth, was isolated from a Indonesian marine sponge of Haliclona sp. The total structure of 1 was determined by spectroscopic study, chemical degradation, and modified Mosher's method. Lembehyne A induced neuritogenesis in pheochromocytoma PC12 cells and neuroblastoma Neuro 2A cells at 2 and 0.1 mug/mL, respectively. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：9945 / 9948

页数：4

共 25 条

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