A stabilized formulation of IBX (SIBX) for safe oxidation reactions including a new oxidative demethylation of phenolic methyl aryl ethers

被引:168
作者
Ozanne, A
Pouységu, L
Depernet, D
François, B
Quideau, S
机构
[1] Inst Europeen Chim & Biol, F-33607 Pessac, France
[2] Univ Bordeaux 1, Ctr Rech Chim Mol, Lab Chim Substances Vegetales, F-33405 Talence, France
[3] SIMAFEX, F-17230 Marans, France
关键词
D O I
10.1021/ol0349965
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
graphics SIBX is a nonexplosive formulation of IBX that can be used as a suspension in a variety of standard organic solvents such as refluxing EtOAc and THF to oxidize safely alcohols into aidehydes and ketones. The use of hot THF is limited to the oxidation of allylic and benzylic alcohols. Most yields are comparable to those obtained with IBX or DMIP. SIBX can also be used to perform oxygenative demethylation of 2-methoxyarenols into orthoquinones and catechols.
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页码:2903 / 2906
页数:4
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